By now, most of us understand the key difference between CBD and THC. THC is psychoactive. CBD is not. THC causes trippy effects. CBD will not get you high.

But what about THC vs CBD health benefits? Which should you take to treat your ailments? This article will break it down and provide you with the information you need to know.

The THC vs CBD Debate

Inflammatory Bowel Disease

Inflammatory bowel disease refers to Crohn’s disease and ulcerative colitis. It is characterized by chronic inflammation of the gastrointestinal tract. If not properly managed, it can permanently damage the GI tract.

Both CBD and THC have been shown to have positive effects on IBD. However, studies conducted on the matter have not found CBD to help people control Chron’s disease. One study showed it can improve the quality of life for people with Crohn’s disease.

THC has also shown minimal results, but research has found that it can help people who haven’t seen success with other treatments. It is also generally more pharmacologically active than CBD. It has been shown to treat ulcerative colitis when combined with CBD and on its own.

When considering THC vs CBD for IBD, THC is the leader.


CBD is known for its seizure-reducing properties. It may not help everyone with epilepsy, but it has proven to be particularly effective in controlling rare, drug-resistant forms of the disease. It is the active ingredient in Epidiolex, the first and only FDA-approved prescription cannabidiol to treat seizures associated with Lennox-Gastaut Syndrome and Dravet syndrome.

THC is not known to be as effective in treating seizures. However, researchers have found that a THC-equivalent compound in the brain can calm epileptic seizures. But they can also increase memory loss.

THC vs CBD for seizures? CBD is the obvious choice.

Depression and Anxiety

Both CBD and THC can reduce depression and anxiety. However, for some people, THC makes depression and anxiety worse.

THC helps reduce depression and anxiety by boosting anandamide production. Anandamide is responsible for providing the feeling of a “runner’s high”. It boosts euphoria to aid with depression.

Marijuana can also regulate sleep and reduce the impact of traumatic memory. Both effects can be beneficial to mood.

However, some people experience negative effects from THC. It can down-regulate the endocannabinoid system in certain people. It can reduce mental health.

It is rare for people to experience a worsening mood on THC, but it is possible.

CBD works similarly, only it promotes the production of the feel-good hormones serotonin and dopamine. It activates adenosine pathways that help with relaxation and open serotonin pathways. It blocks the reuptake of serotonin and dopamine so the body can use them for longer periods.

There is no evidence of CBD worsening mood.

When considering THC vs CBD for depression and anxiety, opinions will differ. But CBD is a safer bet.  

Pain and Inflammation

There are no studies that establish whether THC vs CBD is better for pain and inflammation. Angela D. Bryan, Ph.D. and professor of psychology and neuroscience at the University of Colorado Boulder, believes a combination of the two is necessary. “CBD has anti-inflammatory properties while THC has properties that help us cope with pain,” she says.

THC activates nerve cells to reduce the sensation of pain. CBD boosts serotonin production to reduce feelings of pain. However, there is speculation that it may offer more of a placebo effect.

Studies have shown CBD to reduce inflammation so it works well with THC to reduce pain.


Both THC and CBD have been shown to improve migraine pain. A University of Colorado study of people who get regular migraines used various marijuana products to reduce their symptoms.  They found that THC was most effective and helped reduce their migraines by half.

A second study showed a THC/CBD combination helped with migraine pain relief. A 200 mg product containing 19% THC and 9% CBD was shown to reduce headache pain by 55%. In another phase, patients were given a 200mg dose of the same mix for 3 months and saw a 40.4% improvement.

THC vs CBD for migraines? Both can help but THC is more effective.


THC has long been used to treat glaucoma symptoms. Can CBD provide similar effects?

Studies conducted in the 1970s showed that THC can reduce intraocular pressure, a glaucoma symptom that leads to additional damage to the optic nerve and can lead to peripheral vision loss and blindness. It is most effective when inhaled. THC drops did not yield any improvements. Effects were shown to last 2-4 hours.

CBD, in contrast, has not been shown to yield any improvements in glaucoma patients. It may even increase IOP. So, when it comes to THC vs CBD for glaucoma, THC is the winner.


Cannabis has been shown to help with nausea that occurs in chemotherapy patients. While CBD may provide some nausea relief, THC is a more effective cannabinoid for the task.

It is believed that marijuana helps with nausea by slowing down digestion in the gastrointestinal tract. It also affects the brain to prevent nauseating sensations. It can also be used to increase appetite in people using cancer-fighting medications.

In the case of THC vs CBD for nausea, THC comes out ahead.


Both THC and CBD treat insomnia, but they do it in different ways.

THC has sedative properties. It will make you feel sleepy immediately. This reaction is especially true of sativa weed.

CBD combats sleepiness during the day but helps you sleep at night. It may not be as effective in knocking you out. But it can reduce anxiety that contributes to sleep issues.

If you are wondering THC vs CBD, which is better for sleep, you may want to use a combination of the two.

Both THC and CBD benefit health in different ways. Consider which is best suited to your condition. The psychoactive properties should also come into play in your THC vs CBD decision.

South Coast Safe Access carries various CBD and THC products that benefit health. You can count on us for quality products that are effective as advertised. Contact us to learn more about what we have to offer.